Simons Center for Quantitative Biology
Cold Spring Harbor Laboratory
One Bungtown Road
Cold Spring Harbor, NY 11724
xanderxue at gmail dot com
My research interests consist of developing and applying novel comparative population genomic methods. I am currently a postdoc in Adam C. Siepel's lab, where I am working on a project that involves building a likelihood model to detect the selective dynamics underlying a complex polygenic trait by using GWAS summary statistics.
In my former postdoc with Andrew D. Kern, I developed a machine learning approach that deployed deep convolutional neural networks for detecting selective sweeps, notably partial/incomplete hard and soft sweeps. This method was applied to whole-genome data for eight Anopheles mosquito populations to infer genomic responses to insecticide use, which will be used to inform malaria management.
For my PhD , which I finished under the supervision of Michael J. Hickerson, I primarily developed hierarchical co-demographic modeling approaches given genomic-scale data across multiple independent taxa. In addition, I investigated the effect of purifying selection on transposable elements, and in turn genomic architecture, in model vertebrate organisms within a comparative demographic framework.
Prior to my PhD education, I was a New York City Teaching Fellow, where I earned my Masters of Science for Teachers degree under the supervision of James F. Kilbane and worked as a secondary school teacher in NYC public middle schools and high schools. During this time, I taught biology, general science, mathematics, special education, and English for English Language Learners.